Figure 3 Melanosome transport from center to dendritic tip occurs along microtubule. The movement of melanosome is bidirectional, and kinesins and dyneins work in opposite direction. Myosin Va (myoVa) is a motor protein that attaches to melanosomes through interaction with linker protein melanophilin (mlph) and Rab27a. The tripartite complex helps in melanosome transport and membrane trafficking to keratinocyte. Defect in various components of tripartite complex leads to different variants of Griscelli syndrome with a common feature of perinuclear accumulation of melanosomes.