Home About us Editorial board Ahead of print Current issue Archives Instructions Submit article Search Subscribe Contacts Login
  • Users Online: 185
  • Home
  • Print this page
  • Email this page
CASE REPORT
Year : 2019  |  Volume : 6  |  Issue : 1  |  Page : 37-42

Mucocutaneous hyperpigmentation as presentation of vitamin B12 deficiency: A case report and brief review


Department of Dermatology, Venereology and Leprosy, D.Y. Patil Vidyapeeth Society, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India

Correspondence Address:
Dr. Kirti S Deo
Associate Professor, G-11, Gokhale Vrindavan, Near Chapekar Chowk, Chinchwad, Pune 411033
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/Pigmentinternational.Pigmentinternational_

Rights and Permissions

Vitamin B12 deficiency presents usually with hematologic, gastrointestinal, neurologic, and less commonly, psychiatric, cardiovascular, and dermatological manifestations. A 20-year-old female presented with palmoplantar hyperpigmentation, accentuated over creases and knuckles. She also had intertriginous, perioral/intraoral hyperpigmentation, and gray, thin, lustreless hair. She consumed nonvegetarian diet occasionally. Histopathology revealed increased pigmentation of stratum malpighii. Hemoglobin, vitamin B12, and folate levels were reduced; RBC indices, deranged and parietal cell antibodies, weakly reactive. Pernicious anemia was diagnosed; the patient responded to intramuscular cobalamin injections. Review of Indian and global cases/case series of this deficiency with mucocutaneous presentation iterates knuckle hyperpigmentation to be its prime clinical marker. However, the nonvegetarians comprising a majority of participants in case series from India of vitamin B12 deficiency presenting with hyperpigmentation is confounding and necessitates reassessment with larger future studies. Moreover, increased awareness of the mucocutaneous signs—often nonspecific, subtle, or asymptomatic—of this widely pervasive deficiency among Indians may facilitate prompt management and rectify underreporting.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1009    
    Printed49    
    Emailed0    
    PDF Downloaded90    
    Comments [Add]    

Recommend this journal