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ORIGINAL ARTICLE
Year : 2016  |  Volume : 3  |  Issue : 1  |  Page : 11-16

Study of efficacy of phototherapy (psoralen with ultraviolet A and narrow-band ultraviolet B) in vitiligo


Department of Dermatology, K.E.M. Hospital, Pune, Maharashtra, India

Correspondence Address:
Dr. Aparna Vijay Gaikwad
Department of Dermatology, K.E.M. Hospital, Rasta Peth, Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2349-5847.184263

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Background: Vitiligo is the most common depigmenting disorder. It is more significant in the dark-skinned population, with a major impact on the quality of life of patients. Phototherapy has been the mainstay of treatment for a long time. Both psoralens with ultraviolet A (PUVA) and narrow-band ultraviolet B (NB-UVB) therapy have shown satisfactory results. Aims: To study the efficacy of phototherapy (PUVA and NB-UVB) in patients with vitiligo and to compare the response to phototherapy (PUVA vs. NB-UVB) in vitiligo. Methods: This is a prospective study of 60 patients recruited from the patients attending the dermatology outpatient department of KEM Hospital, Pune. Thirty patients each were randomly allotted to either PUVA or NB-UVB group. Therapy was given thrice a week for PUVA and twice a week for NB-UVB on nonconsecutive days. Patients were followed-up every month for 1 year. Two primary parameters, repigmentation and arrest of progression of disease activity, were considered. Results: Our study showed that both PUVA and NB-UVB are effective in the treatment of vitiligo. Both treatment methods showed a good repigmentation especially over the face, with a poor response on the feet and hands. The overall grade of repigmentation was better with NB-UVB than PUVA. The adverse effects were marginally more with PUVA therapy. Conclusion: Thus, it was proven in our study that both PUVA and NB-UVB are effective for the treatment of vitiligo. However, NB-UVB has proved to have a distinct edge over PUVA in terms of better efficacy and lesser adverse effects.


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